The world system and the things of the world are like chemotherapy to a cancer patient. Chemo is a poison that actually takes away the taste and desire for food that we need for growth and health. Jesus taught us this in the parable of the sower:
Mark 4:18 And these are they which are sown among thorns; such as hear the word, 19 And the cares of this world, and the deceitfulness of riches, and the lusts of other things entering in, choke the word, and it becometh unfruitful. The ungodly and unholy things of the world are like poison to the soul. Like chemotherapy, they kill the desire for the things of God.
The only way that we find satisfaction as Christians is when we desire and then decide to live for the will of God, and not ourselves.
John 4:34 Jesus saith unto them, My meat is to do the will of him that sent me, and to finish his work. John 6:38 For I came down from heaven, not to do mine own will, but the will of him that sent me. Only Jesus can say, satisfaction guaranteed.
